CRMD’s research program is one of the largest in the country for a community-based practice and rivals those of some of the largest academic medical centers. Through clinical trials, Dr. Tolentino is devoted to the development of treatments for retinal diseases like Age-Related Macular Degeneration, Drusen, Diabetic Macular Edema and Retinal Vein Occlusions. CRMD’s certified research staff works closely with bioscience companies, pharmaceutical corporations and the federal government, in order to advance procedures and treatments for the diseases that affect our patients. These innovative treatments, generated by advanced technology, allow the Center for Retina and Macular Disease to potentially offer new options to our patients long before they are accessible to the public.
For more information regarding participation in a clinical research trials,
please contact our office at 863/297-5400 to set up an appointment with a
physician for an evaluation. Patients who then qualify for a clinical trial are
offered cutting-edge technology at no cost.
For an extensive list of our previous clinical trials, click here.
Listed below are the clinical trials that are currently enrolling or will begin
enrolling soon at CRMD:
Wet Age-Related Macular Degeneration
GSK - Protocol Number: MD7110852
A Phase 2b Dose-Ranging Study of Pazopanib Eye Drops versus Ranibizumab Intravitreal
Injections for the Treatment of Neovascular Age-Related Macular Degeneration
GSK - Protocol Number: MD1114155
An open-label pilot study to evaluate the safety, tolerability, pharmacokinetics, exploratory efficacy and pharmacodynamics of oral pazopanib administered for 28 days to neovascular age-related macular degeneration patients
Novartis - Protocol Number: LFG316A2102
A Multicenter, Open Label, Single Ascending Dose Study To Assess The Safety, Tolerability, And Serum Pharmacokinetics Of Intravitreal LFG316 In Patients With Advanced Age-Related Macular Degeneration
Ophthotech - Protocol Number: OPH1001
A Phase 1 Study To Establish The Safety And Tolerability Of ARC1905 (ANTI-C5 APTAMER) In Subjects With Dry Age-Related Macular Degeneration
Geographic Atrophy
Pfizer - Protocol Number: B1181002
A Phase 1, Double-Masked, Placebo-Controlled Study Evaluating The Safety, Tolerability, Immunogenicity, Pharmacokinetics, And Pharmacodynamics Of Multiple Escalating Dosages Of Rn6g In Subjects With Advanced Dry, Age-Related Macular Degeneration (AMD) Including Geographic Atrophy
Genentech - Protocol Number: CFD4870g
Phase Ib/II, Multicenter, Randomized, Single-Masked, Sham Injection-Controlled Study Of Safety, Tolerability, And Evidence Of Activity Of CFD4514S Intravitreal Injections Administered Monthly Or Every Other Month To Patients With Geographic Atrophy
Novartis – Protocol Number: PJMR0092103
Epidemiologic Study of Patients with Geographic Atrophy Due to Age-Related Macular
Degeneration
Diabetic Macular Edema
Investigator Sponsored (PRESERVE)
Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease
Non-Arteritic Anterior Ischemic Optic Neuropathy
Bayer - Protocol Number: 12912
Prospective Case Crossover Study to Assess Whether PDE5 Inhibitor Exposure in Men with Erectile Dysfunction Increases the Risk for the Development of Non-arteritic Anterior Ischemic Optic Neuropathy